PRODUCT IDENTIFICATION
H.S. CODE
TOXICITY
Vincrisul;
VCR; LCR;
Methyl(3aR,4R,5S,5aR,10bR,12bR)-4-acetoxy-3a-ethyl-9-[(3R,5S,7R,9S)-
5-ethyl-5- hydroxy-9-methoxycarbonyl-1,4,5,6,7,8,9,10-octahydro-
3,7
-methano-3-azacyclo undecino
[5,4-b]indol- 9-yl]-6-formyl-5-hydroxy- 8-methoxy-3a,4,5,5a,6,11, 12,13a-octahydro-
1H-indolizino [8,1-ca]carbazole-5- carboxylate,
monosulfate;
22-oxovincaleukoblastine sulfate (1:1) (salt);
des-na-methyl-na-formylvinblastine sulfate; LCR sulfate; Leurocristine sulfate;
Leurocristine sulfate (1:1);
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
AUTOIGNITION
NFPA RATINGS
REFRACTIVE INDEX
APPLICATIONS
Vincristine Sulfate is the sulfate salt of a vinca alkaloid obtained from
the periwinkle plant (Vinca rosea Linn). It is a white to off-white powder;
soluble in water and methanol; slightly soluble in 95% ethanol. The chemical
designation is
Methyl(3aR,4R,5S,5aR,10bR,12bR)-4-acetoxy- 3a-ethyl- 9-[(3R,5S,7R,9S)- 5-ethyl-5-
hydroxy-9-methoxycarbonyl-1,4,5,6,7,8,9,10-octahydro-
3,7
-methano- 3-azacyclo undecino
[5,4-b]indol- 9-yl]-6- formyl-5-hydroxy- 8-methoxy-3a,4,5,5a,6,11, 12,13a-octahydro-
1H-indolizino [8,1-ca]carbazole-5- carboxylate,
monosulfate. It is an inhibitor
of monoamine oxidase B. It is used as an antineoplastic agent, administered intravenously,
as a component of combination chemotherapy regimens for Hodgkin's disease
primarily and for acute lymphocytic leukemia, non-Hodgkin's lymphomas, Wilms'
tumor, neuroblastoma, breast carcinoma, rhabdomyosarcoma, multiple myeloma,
soft-tissue sarcomas, osteogenic sarcoma, other sarcomas and certain brain
tumors. It is widely used on cancer research and multi-drug resistance.
APPEARANCE
IDENTIFICATION
Complies
ASSAY (HPLC)
-110° ~ -118°
LOSS ON DRYING
12.0% max
pH
3.5 - 4.5
10ppm max
INDIVIDUAL IMPURITY
2.0% max (total impurity: 5.0% max)
PRICE INFORMATION